Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues.

ABSTRACT: Recent evidence suggests that the PRL-1 and -2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. Northern blotting has previously shown widespread expression of both transcripts; however, little is known about the cell type-specific expression of either gene, especially in human tissues. Therefore, we investigated expression patterns for PRL-1 and -2 genes in multiple normal, adult human tissues using in situ hybridization. Although both transcripts were ubiquitously expressed, they exhibited strikingly different patterns of expression. PRL-2 was expressed heavily in almost every tissue and cell type examined, whereas PRL-1 expression levels varied considerably both between tissue types and between individuals. Widespread expression of PR

SUBMITTER: Dumaual CM 

PROVIDER: S-EPMC3958126 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature