A PDMS-based cylindrical hybrid lens for enhanced fluorescence detection in microfluidic systems.

ABSTRACT: Microfluidic systems based on fluorescence detection have been developed and applied for many biological and chemical applications. Because of the tiny amount of sample in the system; the induced fluorescence can be weak. Therefore, most microfluidic systems deploy multiple optical components or sophisticated equipment to enhance the efficiency of fluorescence detection. However, these strategies encounter common issues of complex manufacturing processes and high costs. In this study; a miniature, cylindrical and hybrid lens made of polydimethylsiloxane (PDMS) to improve the fluorescence detection in microfluidic systems is proposed. The hybrid lens integrates a laser focusing lens and a fluorescence collecting lens to achieve dual functions and simplify optical setup. Moreover, PDMS has a

SUBMITTER: Lin BS 

PROVIDER: S-EPMC3958222 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature