Genetic diversity and prevalence of CCR2-CCR5 gene polymorphisms in the Omani population.

ABSTRACT: Polymorphisms in the regulatory region of the CCR5 gene affect protein expression and modulate the progress of HIV-1 disease. Because of this prominent role, variations in this gene have been under differential pressure and their frequencies vary among human populations. The CCR2V64I mutation is tightly linked to certain polymorphisms in the CCR5 gene. The current Omani population is genetically diverse, a reflection of their history as traders who ruled extensive regions around the Indian Ocean. In this study, we examined the CCR2-CCR5 haplotypes in Omanis and compared the patterns of genetic diversity with those of other populations. Blood samples were collected from 115 Omani adults and genomic DNA was screened to identify the polymorphic sites in the CCR5 gene and the CCR2V64I mutation

SUBMITTER: Al-Mahruqi SH 

PROVIDER: S-EPMC3958329 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature