IL-28B polymorphisms correlated with treatment response in HCV-4 mono-infected patients: a meta-analysis.

ABSTRACT:

Background

The role of interleukin 28B (IL-28B) polymorphisms played in hepatitis C virus (HCV) infection has been gradually explicit, especially in HCV genotype 1, 2 and 3. However, no confirmative conclusion was acquired in genotype 4 HCV patients. Thus we conducted this meta-analysis.

Methods

We searched the commonly used databases both in English and Chinese. Meta-analysis was performed in fixed/random effects models using STATA 12.0 or R software. Publication bias was examined through Egger's test and Begg's funnel plot.

Results

In total, 11 studies were included in this meta-analysis, encompassing 1284 patients who were mono-infected with HCV-4 and received Peg-interferon (Peg-IFN) plus Ribavirin (Rbv). Around 53.0% patients would achieve sustained virologic res

SUBMITTER: Liu T 

PROVIDER: S-EPMC3958354 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature