The association between RAD23B Ala249Val polymorphism and cancer susceptibility: evidence from a meta-analysis.

ABSTRACT:

Background

A number of studies have investigated associations of genetic variation in RAD23B Ala249Val (rs1805329 C>T) with cancer susceptibility; however, the findings are inconsistent. We performed a meta-analysis to acquire a more precise estimation of the relationship.

Method

We searched literatures from PubMed, Embase and Web of Science. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association between Ala249Val polymorphism and cancer risk.

Results

A total of 23 studies consisting of 10837 cases and 13971 controls were included in this meta-analysis. Overall, no significant associations were found between RAD23B Ala249Val polymorphism and cancer risk (Val/Val vs. Ala/Ala: OR = 0.97, 95% CI = 0.75-1.25; Ala/Val vs. Al

SUBMITTER: Li Z 

PROVIDER: S-EPMC3958435 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature