Polymorphisms of the LTA gene may contribute to the risk of myocardial infarction: a meta-analysis.

ABSTRACT:

Objective

The lymphotoxin-α (LTA), as one of the mediators of inflammation, may play an important role in the pathogenesis of myocardial infarction (MI). Genetic association studies (GAS) that have investigated the association between three common polymorphisms (A252G, G10A and C804A) of the LTA gene and susceptibility to MI have produced contradictory and inconclusive results. The aim of this meta-analysis is to provide a relatively comprehensive account of the association of these polymorphisms with susceptibility to MI.

Methods

A literature search for eligible GAS published before October 15, 2013 was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and CNKI (China National Knowledge Infrastructure) databases. We performed a meta-analysis of fifteen case

SUBMITTER: Li N 

PROVIDER: S-EPMC3958506 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature