Night blood pressure responses to atenolol and hydrochlorothiazide in black and white patients with essential hypertension.

ABSTRACT:

Background

Night blood pressure (BP) predicts patient outcomes. Variables associated with night BP response to antihypertensive agents have not been fully evaluated in essential hypertension.

Methods

We sought to measure night BP responses to hydrochlorothiazide (HCTZ), atenolol (ATEN), and combined therapy using ambulatory blood pressure (ABP) monitoring in 204 black and 281 white essential hypertensive patients. Initial therapy was randomized; HCTZ and ATEN once daily doses were doubled after 3 weeks and continued for 6 more weeks with the alternate medication added for combined therapy arms. ABP was measured at baseline and after completion of each drug. Night, day, and night/day BP ratio responses (treatment - baseline) were compared in race/sex subgroups.

Results

SUBMITTER: Chapman AB 

PROVIDER: S-EPMC3958600 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature