ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.

ABSTRACT: Bacterial cell division requires the formation of a mature divisome complex positioned at the midcell. The localization of the divisome complex is determined by the correct positioning, assembly, and constriction of the FtsZ ring (Z-ring). Z-ring constriction control remains poorly understood and (to some extent) controversial, probably due to the fact that this phenomenon is transient and controlled by numerous factors. Here, we characterize ZapE, a novel ATPase found in Gram-negative bacteria, which is required for growth under conditions of low oxygen, while loss of zapE results in temperature-dependent elongation of cell shape. We found that ZapE is recruited to the Z-ring during late stages of the cell division process and correlates with constriction of the Z-ring. Overexpression or

SUBMITTER: Marteyn BS 

PROVIDER: S-EPMC3958796 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature