IRSpot-TNCPseAAC: identify recombination spots with trinucleotide composition and pseudo amino acid components.

ABSTRACT: Meiosis and recombination are the two opposite aspects that coexist in a DNA system. As a driving force for evolution by generating natural genetic variations, meiotic recombination plays a very important role in the formation of eggs and sperm. Interestingly, the recombination does not occur randomly across a genome, but with higher probability in some genomic regions called "hotspots", while with lower probability in so-called "coldspots". With the ever-increasing amount of genome sequence data in the postgenomic era, computational methods for effectively identifying the hotspots and coldspots have become urgent as they can timely provide us with useful insights into the mechanism of meiotic recombination and the process of genome evolution as well. To meet the need, we developed a new p

SUBMITTER: Qiu WR 

PROVIDER: S-EPMC3958819 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature