Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls.

ABSTRACT: Multiple sclerosis (MS) is an inflammatory CNS disease with a substantial genetic component, originally mapped to only the human leukocyte antigen (HLA) region. In the last 5 years, a total of seven genome-wide association studies and one meta-analysis successfully identified 57 non-HLA susceptibility loci. Here, we merged nominal statistical evidence of association and physical evidence of interaction to conduct a protein-interaction-network-based pathway analysis (PINBPA) on two large genetic MS studies comprising a total of 15,317 cases and 29,529 controls. The distribution of nominally significant loci at the gene level matched the patterns of extended linkage disequilibrium in regions of interest. We found that products of genome-wide significantly associated genes are more likely to

SUBMITTER: International Multiple Sclerosis Genetics Consortium 

PROVIDER: S-EPMC3958952 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature