Neutrophil-lymphocyte ratio as a predictor of cognitive dysfunction in carotid endarterectomy patients.

ABSTRACT:

Background

Systemic inflammation has been implicated in the development of cognitive dysfunction following carotid endarterectomy (CEA). Neutrophil-lymphocyte ratio (NLR) is a reliable measure of systemic inflammation. We hypothesize that patients with elevated preoperative NLR have increased risk of cognitive dysfunction 1 day after CEA.

Methods

Five hundred fifty-one patients scheduled for CEA were enrolled at Columbia University in New York, NY from 1995 to 2012. NLR was retrospectively reviewed; only 432 patients had preoperative NLR values available within 2 weeks of CEA. NLR was analyzed as a continuous variable and categorically with a cutoff of ≥5 and <5 and equal tertiles, as done in previous studies.

Results

Patients with cognitive dysfunction had significan

SUBMITTER: Halazun HJ 

PROVIDER: S-EPMC3959110 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature