Cardiometabolic risk in overweight subjects with or without relative fat-free mass deficiency: the Strong Heart Study.

ABSTRACT:

Background and aim

Sarcopenia is a condition mainly due to loss of fat-free mass (FFM) in elderly individuals. RFFMD, however, is also frequent in obese subjects due to abnormal body composition. Objective of this study was to evaluate the impact of relative fat-free mass deficiency (RFFMD) on cardiometabolic (CM) risk in obese normoglycemic individuals.

Methods and results

Overweight/obese American Indians from the Strong Heart Study population, without diabetes and with FBG ≤ 110 mg/dL and with GFR >60 mg/mL/1.73 m(2) were selected for this analysis (n = 742). RFFMD was defined on the basis of a multivariable equation previously reported. Fasting glucose and 2 h-OGTT were measured together with urine albumin/creatinine excretion, laboratory and anthropometric parameters. I

SUBMITTER: Ferrara LA 

PROVIDER: S-EPMC3959567 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature