ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.

ABSTRACT: Despite the clear major contribution of hyperlipidemia to the prevalence of cardiovascular disease in the developed world, the direct effects of lipoproteins on endothelial cells have remained obscure and are under debate. Here we report a previously uncharacterized mechanism of vessel growth modulation by lipoprotein availability. Using a genetic screen for vascular defects in zebrafish, we initially identified a mutation, stalactite (stl), in the gene encoding microsomal triglyceride transfer protein (mtp), which is involved in the biosynthesis of apolipoprotein B (ApoB)-containing lipoproteins. By manipulating lipoprotein concentrations in zebrafish, we found that ApoB negatively regulates angiogenesis and that it is the ApoB protein particle, rather than lipid moieties within ApoB-cont

SUBMITTER: Avraham-Davidi I 

PROVIDER: S-EPMC3959651 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature