Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis.

ABSTRACT:

Objective

We investigated potential interactions between human leukocyte antigen (HLA) genotype and body mass index (BMI) status in relation to the risk of developing multiple sclerosis (MS).

Methods

We used 2 case-control studies, one with incident cases (1,510 cases, 2,017 controls) and one with prevalent cases (937 cases, 609 controls). Subjects with different genotypes and BMI were compared with regard to incidence of MS by calculating odds ratios (ORs) with 95% confidence intervals (CIs) employing logistic regression. Potential interactions between genotypes and BMI were evaluated by calculating the attributable proportion due to interaction.

Results

In both cohorts, a significant interaction was observed between HLA-DRB1*15 and obesity, regardless of HLA-A*02 st

SUBMITTER: Hedstrom AK 

PROVIDER: S-EPMC3959752 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature