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Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines.

ABSTRACT: A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in toluene. The absolute configuration of such addition products has been determined by x-ray crystallography.

SUBMITTER: Wei C

PROVIDER: S-EPMC395979 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature

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Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines.

Wei Chunmei C Mague Joel T JT Li Chao-Jun CJ

Proceedings of the National Academy of Sciences of the United States of America 20040405 16

A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in toluene. The absolute configuration of such addition products has been determined by x-ray crystallography. ...[more]

PMID: 15067132

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