Treatment with omega-3 fatty acid ethyl-ester alters fatty acid composition of lipoproteins in overweight or obese adults with insulin resistance.

ABSTRACT:

Introduction

The effects of dietary fatty acid supplementation on lipoprotein fatty acid composition have rarely been described.

Patients and methods

Sixty-one overweight and obese adults with dyslipidemia and insulin resistance were randomized to placebo, 2g/day extended-release nicotinic acid (ERN), 4g/day prescription omega-3 fatty acid ethyl ester (P-OM3), or combination therapy for 16 weeks. Lipoprotein fatty acid composition was analyzed by gas chromatography pre- and post-treatment.

Results

Treatment with P-OM3 or combination, but not ERN, increased proportions of eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, and reduced those for arachidonic acid in all lipoprotein fractions, with greatest impact in the high-density lipoprotein fracti

SUBMITTER: Augustine AH 

PROVIDER: S-EPMC3959884 | biostudies-literature | 2014 Feb-Mar

REPOSITORIES: biostudies-literature