Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial.

ABSTRACT:

Importance

Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence.

Objective

To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers.

Design, setting, and participants

Randomized, blinded, placebo-controlled multicenter clinical trial with a 12-week treatment period and follow-up through week 52 conducted between October 2009 and April 2013 at 3 midwestern clinical research sites. Five hundred six adult (≥18 years) cigarette smokers were randomly assigned and 315 (62%) completed the study.

Interventions

Twelve weeks of varenicline and bupropion SR or varenicline and placebo.

Main outcomes and measures

Primar

SUBMITTER: Ebbert JO 

PROVIDER: S-EPMC3959999 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature