Applying mass spectrometry-based qualitative proteomics to human amygdaloid complex.

ABSTRACT: The amygdaloid complex is a key brain structure involved in the expression of behaviors and emotions such as learning, fear, and anxiety. Brain diseases including depression, epilepsy, autism, schizophrenia, and Alzheimer's disease, have been associated with amygdala dysfunction. For several decades, neuroanatomical, neurophysiological, volumetric, and cognitive approaches have been the gold standard techniques employed to characterize the amygdala functionality. However, little attention has been focused specifically on the molecular composition of the human amygdala from the perspective of proteomics. We have performed a global proteome analysis employing protein and peptide fractionation methods followed by nano-liquid chromatography tandem mass spectrometry (nanoLC-MS/MS), detecting ex

SUBMITTER: Fernandez-Irigoyen J 

PROVIDER: S-EPMC3960493 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature