Microevolution of Renibacterium salmoninarum: evidence for intercontinental dissemination associated with fish movements.

ABSTRACT: Renibacterium salmoninarum is the causative agent of bacterial kidney disease, a major pathogen of salmonid fish species worldwide. Very low levels of intra-species genetic diversity have hampered efforts to understand the transmission dynamics and recent evolutionary history of this Gram-positive bacterium. We exploited recent advances in the next-generation sequencing technology to generate genome-wide single-nucleotide polymorphism (SNP) data from 68 diverse R. salmoninarum isolates representing broad geographical and temporal ranges and different host species. Phylogenetic analysis robustly delineated two lineages (lineage 1 and lineage 2); futhermore, dating analysis estimated that the time to the most recent ancestor of all the isolates is 1239 years ago (95% credible interval (CI) 4

SUBMITTER: Brynildsrud O 

PROVIDER: S-EPMC3960531 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature