Integrated transcriptomic and proteomic analysis of the global response of Wolbachia to doxycycline-induced stress.

ABSTRACT: The bacterium Wolbachia (order Rickettsiales), representing perhaps the most abundant vertically transmitted microbe worldwide, infects arthropods and filarial nematodes. In arthropods, Wolbachia can induce reproductive alterations and interfere with the transmission of several arthropod-borne pathogens. In addition, Wolbachia is an obligate mutualist of the filarial parasites that cause lymphatic filariasis and onchocerciasis in the tropics. Targeting Wolbachia with tetracycline antibiotics leads to sterilisation and ultimately death of adult filariae. However, several weeks of treatment are required, restricting the implementation of this control strategy. To date, the response of Wolbachia to stress has not been investigated, and almost nothing is known about global regulation of gene e

SUBMITTER: Darby AC 

PROVIDER: S-EPMC3960535 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature