TGFBI expression is an independent predictor of survival in adjuvant-treated lung squamous cell carcinoma patients.

ABSTRACT:

Background

Transforming growth factor β-induced protein (TGFBI) is a secreted protein that mediates cell anchoring to the extracellular matrix. This protein is downregulated in lung cancer, and when overexpressed, contributes to apoptotic cell death. Using a small series of stage IV non-small cell lung cancer (NSCLC) patients, we previously suggested the usefulness of TGFBI as a prognostic and predictive factor in chemotherapy-treated late-stage NSCLC. In order to validate and extend these results, we broaden the analysis and studied TGFBI expression in a large series of samples obtained from stage I-IV NSCLC patients.

Methods

TGFBI expression was assessed by immunohistochemistry in 364 completely resected primary NSCLC samples: 242 adenocarcinomas (ADCs) and 122 squamous ce

SUBMITTER: Pajares MJ 

PROVIDER: S-EPMC3960613 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature