Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis.

ABSTRACT:

Background

The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes.

Methods

Ovid MEDLINE and EMBASE were searched to identify studies reporting the prognostic significance of tumour-infiltrating inflammation for patients with CRC. The primary outcome measures were overall survival (OS), cancer-specific survival (CS) and disease-free survival (DFS).

Results

A total of 30 studies involving 2988 patients were identified. Studies were subdivided into those considering the associations between CRC survival and generalised tumour inflammatory infiltrate (n=12) and T lympho

SUBMITTER: Mei Z 

PROVIDER: S-EPMC3960618 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature