High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment.

ABSTRACT:

Background

Forkhead Box P3 (FoxP3) is thought to be a key transcription factor in regulatory T cells (Tregs), and recent data indicate that it is expressed in several tumour cells. However, its precise roles in gastric cancer (GC) and the underlying mechanisms regulating the interaction between GC cells and lymphocytes remain unclear.

Methods

FoxP3 expression was examined in tumour cells and Tregs in 150 cases of gastric precancer and cancer, and their prognostic significances were evaluated, respectively, using a tissue microarray containing 135 GC patient samples with a mean 102-month follow-up. FoxP3 involvement in the tumour cells-lymphocytes interaction and its gene function were further investigated.

Results

strong cytoplasmic staining of FoxP3 was observed in G

SUBMITTER: Ma GF 

PROVIDER: S-EPMC3960619 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature