Prediction of tumour response induced by chemotherapy using modelling of CA-125 kinetics in recurrent ovarian cancer patients.

ABSTRACT:

Background

The main objective of the present study was to establish the relationships between CA-125 kinetics and tumour size changes during treatment.

Methods

The data from the CALYPSO-randomised phase III trial, comparing two platinum-based regimens in recurrent ovarian cancer (ROC) patients, was randomly split into a 'learning data set' to estimate model parameters and a 'validation data set' to validate model performances. A kinetic-pharmacodynamic semi-mechanistic model was built to describe tumour size and CA-125 kinetics during chemotherapy. The ability of the model to predict tumour response induced by chemotherapy, based on CA-125 values, was assessed.

Results

Data from 535 ROC patients were used to model CA-125 kinetics and tumour size changes during the fir

SUBMITTER: Wilbaux M 

PROVIDER: S-EPMC3960627 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature