Host genetic variants of ABCB1 and IL15 influence treatment outcome in paediatric acute lymphoblastic leukaemia.

ABSTRACT:

Background

Host germline variations and their potential prognostic importance is an emerging area of interest in paediatric ALL.

Methods

We investigated the associations between 20 germline variations and various clinical end points in 463 children with ALL.

Results

After adjusting for known prognostic factors, variants in two genes were found to be independently associated with poorer EFS: ABCB1 T/T at either 2677 (rs2032582) or 3435 (rs1045642) position (P=0.003) and IL15 67276493G/G (rs17015014; P=0.022). These variants showed a strong additive effect affecting outcome (P<0.001), whereby patients with both risk genotypes had the worst EFS (P=0.001), even after adjusting for MRD levels at the end of remission induction. The adverse effect of ABCB1 T/T genotypes was

SUBMITTER: Lu Y 

PROVIDER: S-EPMC3960629 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature