Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS.

ABSTRACT:

Background

Startle inhibition by weak prepulses (PPI) is studied to understand the biology of information processing in schizophrenia patients and healthy comparison subjects (HCS). The Consortium on the Genetics of Schizophrenia (COGS) identified associations between PPI and single nucleotide polymorphisms in schizophrenia probands and unaffected relatives, and linkage analyses extended evidence for the genetics of PPI deficits in schizophrenia in the COGS-1 family study. These findings are being extended in a 5-site "COGS-2" study of 1800 patients and 1200 unrelated HCS to facilitate genetic analyses. We describe a planned interim analysis of COGS-2 PPI data.

Methods

Eyeblink startle was measured in carefully screened HCS and schizophrenia patients (n=1402). Planned analys

SUBMITTER: Swerdlow NR 

PROVIDER: S-EPMC3960985 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature