Computational analyses of synergism in small molecular network motifs.

ABSTRACT: Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their interactions. However, achieving an intuitive understanding of the dynamical properties and responses to stimuli of these networks is hampered by their large scale and complexity. To address this issue, analyses of regulatory networks often focus on reduced models that depict distinct, reoccurring connectivity patterns referred to as motifs. Previous modeling studies have begun to characterize the dynamics of small motifs, and to describe ways in which variations in parameters affect their responses to stimuli. The present study investigates how variations in pairs of parameters affect responses in a series of ten common network motifs,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3961176 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature