Relating structure and function in the human brain: relative contributions of anatomy, stationary dynamics, and non-stationarities.

ABSTRACT: Investigating the relationship between brain structure and function is a central endeavor for neuroscience research. Yet, the mechanisms shaping this relationship largely remain to be elucidated and are highly debated. In particular, the existence and relative contributions of anatomical constraints and dynamical physiological mechanisms of different types remain to be established. We addressed this issue by systematically comparing functional connectivity (FC) from resting-state functional magnetic resonance imaging data with simulations from increasingly complex computational models, and by manipulating anatomical connectivity obtained from fiber tractography based on diffusion-weighted imaging. We hypothesized that FC reflects the interplay of at least three types of components: (i) a b

SUBMITTER: Messe A 

PROVIDER: S-EPMC3961181 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature