Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa.

ABSTRACT:

Objectives

The objective of this study was to investigate the effect of systemically transplanted mesenchymal stem cells (MSCs) on the peri-implant epithelial sealing around dental implants.

Materials and methods

MSCs were isolated from bone marrow of donor rats and expanded in culture. After recipient rats received experimental titanium dental implants in the bone sockets after extraction of maxillary right first molars, donor rat MSCs were intravenously transplanted into the recipient rats.

Results

The injected MSCs were found in the oral mucosa surrounding the dental implants at 24 hours post-transplantation. MSC transplantation accelerated the formation of the peri-implant epithelium (PIE)-mediated mucosa sealing around the implants at an early stage after implant

SUBMITTER: Kondo R 

PROVIDER: S-EPMC3961234 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature