RET and PHOX2B genetic polymorphisms and Hirschsprung's disease susceptibility: a meta-analysis.

ABSTRACT:

Background

Many publications have evaluated the correlation between RET, PHOX2B polymorphisms and Hirschsprung's disease with conflicting results. We performed this meta-analysis to clarify the association of RET, PHOX2B polymorphisms with HSCR.

Methods

We searched Pubmed, Elsevier Science Direct, China National Knowledge Infrastructure database, Chinese Biomedical database, Google scholar. The combined odds ratio (OR) with 95% CI was calculated to estimate the strength of the association. Heterogeneity and publication bias were also assessed.

Results

In total, 16 studies concerning RET and 4 studies concerning PHOX2B were included in the meta-analysis. The effects of five polymorphisms of RET (rs1800858, rs1800860, rs1800861, rs10900297, rs2435357) and one polymorphi

SUBMITTER: Liang CM 

PROVIDER: S-EPMC3961244 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature