Integrative computational and experimental approaches to establish a post-myocardial infarction knowledge map.

ABSTRACT: Vast research efforts have been devoted to providing clinical diagnostic markers of myocardial infarction (MI), leading to over one million abstracts associated with "MI" and "Cardiovascular Diseases" in PubMed. Accumulation of the research results imposed a challenge to integrate and interpret these results. To address this problem and better understand how the left ventricle (LV) remodels post-MI at both the molecular and cellular levels, we propose here an integrative framework that couples computational methods and experimental data. We selected an initial set of MI-related proteins from published human studies and constructed an MI-specific protein-protein-interaction network (MIPIN). Structural and functional analysis of the MIPIN showed that the post-MI LV exhibited increased repres

SUBMITTER: Nguyen NT 

PROVIDER: S-EPMC3961365 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature