Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration.

ABSTRACT: Cell migration is a widespread and complex process that is crucial for morphogenesis and for the underlying invasion and metastasis of human cancers. During migration, cells are steered toward target sites by guidance molecules that induce cell direction and movement through complex intracellular mechanisms. The spatio-temporal regulation of the expression of these guidance molecules is of extreme importance for both normal morphogenesis and human disease. One way to achieve this precise regulation is by combinatorial inputs of different transcription factors. Here we used Drosophila melanogaster mutants with migration defects in the ganglionic branches of the tracheal system to further clarify guidance regulation during cell migration. By studying the cellular consequences of overactivate

SUBMITTER: Buti E 

PROVIDER: S-EPMC3961400 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature