Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review.

ABSTRACT:

Background

New agents with neuroprotective or neuroregenerative potential might be explored in primary-progressive Multiple Sclerosis (PPMS)--the MS disease course with leading neurodegenerative pathology. Identification of patients with a high short-term risk for progression may minimize study duration and sample size. Cohort studies reported several variables as predictors of EDSS disability progression but findings were partially contradictory.

Objective

To analyse the impact of published predictors on EDSS disease progression in a large cohort of PPMS patients.

Methods

A systematic literature research was performed to identify predictors for disease progression in PPMS. Individual case data from the Sylvia Lawry Centre (SLC) and the Hamburg MS patient database (HA

SUBMITTER: Stellmann JP 

PROVIDER: S-EPMC3961431 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature