Mechanistic relationship between membrane type-1 matrix metalloproteinase and the myocardial response to pressure overload.

ABSTRACT:

Background

Although matrix metalloproteinases (MMPs) were initially thought to result primarily in extracellular matrix degradation, certain MMP types, such as membrane type-1 (MT1) MMP, may also be involved in profibrotic cascades through hydrolysis of latency-associated transforming growth factor-binding protein (LTBP-1) and activation of transforming growth factor-dependent profibrotic signaling. The present study tested the hypothesis that MT1-MMP plays a direct role in the matrix remodeling response to a left ventricular (LV) pressure overload (PO) stimulus.

Methods and results

Wild-type (WT) and transgenic mice with cardiac-restricted MT1-MMP overexpression or MT1-MMP reduced expression underwent PO for 4 weeks. PO resulted in a 57% increase in LV mass (no change in LV

SUBMITTER: Zile MR 

PROVIDER: S-EPMC3961496 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature