Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing.

ABSTRACT: Since September 2010, more than 10,000 patients have undergone preemptive, panel-based pharmacogenomic testing through the Vanderbilt Pharmacogenomic Resource for Enhanced Decisions in Care and Treatment program. Analysis of the genetic data from the first 9,589 individuals reveals that the frequency of genetic variants is concordant with published allele frequencies. Based on five currently implemented drug-gene interactions, the multiplexed test identified one or more actionable variants in 91% of the genotyped patients and in 96% of African American patients. Using medication exposure data from electronic medical records, we compared a theoretical "reactive," prescription-triggered, serial single-gene testing strategy with our preemptive, multiplexed genotyping approach. Reactive genoty

SUBMITTER: Van Driest SL 

PROVIDER: S-EPMC3961508 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature