Incorporating incretin-based therapies into clinical practice for patients with type 2 diabetes.

ABSTRACT:

Background

Effective, evidence-based management of type 2 diabetes (T2D) requires the integration of the best available evidence with clinical experience and patient preferences.

Methods

Studies published from 2000 to 2012 evaluating glucagon-like peptide-1 receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) were identified using PubMed. The author contextualized the study findings with his clinical experience.

Results

Incretin-based therapy targets multiple dysfunctional organs in T2D. Injectable GLP-1RAs provide substantial glycemic control and weight reduction; while oral DPP-4 inhibitors provide moderate glycemic control and weight neutrality. Both classes are effective, well tolerated, and associated with a low incidence of hypogl

SUBMITTER: Tibaldi JM 

PROVIDER: S-EPMC3961600 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature