Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.

ABSTRACT: Macrophages occur along a continuum of functional states between M1-type polarized macrophages with antiangiogenic and antitumor activity and M2-type polarized macrophages, which have been implicated to promote angiogenesis and tumor growth. Proangiogenic M2-type macrophages promote various pathologic conditions, including choroidal neovascularization in models of neovascular age-related macular degeneration, or certain cancers, such as glioblastoma multiforme. Thus, a potential novel therapeutic approach to target pathological angiogenesis in these conditions would be to inhibit the polarization of macrophages toward the proangiogenic M2-type. However, no pharmacological inhibitors of M2-type macrophage polarization have been identified yet. Here we performed an unbiased pharmacological a

SUBMITTER: He L 

PROVIDER: S-EPMC3961635 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature