Novel ubiquitin-derived high affinity binding proteins with tumor targeting properties.

ABSTRACT: Targeting effector molecules to tumor cells is a promising mode of action for cancer therapy and diagnostics. Binding proteins with high affinity and specificity for a tumor target that carry effector molecules such as toxins, cytokines, or radiolabels to their intended site of action are required for these applications. In order to yield high tumor accumulation while maintaining low levels in healthy tissues and blood, the half-life of such conjugates needs to be in an optimal range. Scaffold-based binding molecules are small proteins with high affinity and short systemic circulation. Due to their low molecular complexity, they are well suited for combination with effector molecules as well as half-life extension technologies yielding therapeutics with half-lives adapted to the specific t

SUBMITTER: Lorey S 

PROVIDER: S-EPMC3961674 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature