Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer.

ABSTRACT:

Background

Altered glucose metabolism is the most common metabolic hallmark of malignancies. The authors tested the hypothesis that glucose metabolism gene variations affect clinical outcome in pancreatic cancer.

Methods

The authors retrospectively genotyped 26 single nucleotide polymorphisms from 5 glucose metabolism genes in 154 patients with localized disease and validated the findings in 552 patients with different stages of pancreatic adenocarcinoma. Association between genotypes and overall survival (OS) was evaluated using multivariate Cox proportional hazard regression models with adjustment for clinical predictors.

Results

Glucokinase (GCK) IVS1 + 9652C > T and hexokinase 2 (HK2) N692N homozygous variants were significantly associated with reduced OS in the t

SUBMITTER: Dong X 

PROVIDER: S-EPMC3961843 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature