Computational approaches for rational design of proteins with novel functionalities.

ABSTRACT: Proteins are the most multifaceted macromolecules in living systems and have various important functions, including structural, catalytic, sensory, and regulatory functions. Rational design of enzymes is a great challenge to our understanding of protein structure and physical chemistry and has numerous potential applications. Protein design algorithms have been applied to design or engineer proteins that fold, fold faster, catalyze, catalyze faster, signal, and adopt preferred conformational states. The field of de novo protein design, although only a few decades old, is beginning to produce exciting results. Developments in this field are already having a significant impact on biotechnology and chemical biology. The application of powerful computational methods for functional protein desi

SUBMITTER: Tiwari MK 

PROVIDER: S-EPMC3962203 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature