MD simulation studies to investigate iso-energetic conformational behaviour of modified nucleosides m(2)G and m(2) 2G present in tRNA.

ABSTRACT: Modified nucleic acid bases are most commonly found in tRNA. These may contain modifications from simple methylation to addition of bulky groups. Methylation of the four canonical nucleotide bases at a wide variety of positions is particularly prominent among the known modification. Methylation of N2 group of guanine is a relatively common modification in tRNA and rRNA. N2-methylguanosine (m(2)G) is the second most often encountered nucleoside in E. coli tRNAs. N2, N2- dimethylguanosine (m(2) 2G) is found in the majority of eukaryotic tRNAs and involved in forming base pair interactions with adjacent bases. Hence, in order to understand the structural significance of these methylated nucleic acid bases we have carried out molecular dynamics simulation to see the salvation effect. The resul

SUBMITTER: Bavi RS 

PROVIDER: S-EPMC3962230 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature