Association between MTHFR C677T and A1298C polymorphisms and NSCL/P risk in Asians: a meta-analysis.

ABSTRACT:

Objective

Several studies have reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and nonsyndromic cleft lip with or without palate (NSCL/P) in Asian populations. However, findings have been conflicting. In order to investigate the association, a meta-analysis was performed.

Methods

We searched Pubmed, MedLine and EmBase database to selected eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated using fixed effects model or random effects model to assess the association between MTHFR polymorphisms and NSCL/P in both Asian children and mothers.

Results

Finally, nine case-control studies were included. Overall, the MTHFR C677T polymorphism and NSCL/P showed pooled ORs

SUBMITTER: Zhao M 

PROVIDER: S-EPMC3962346 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature