The emergence of resistance to fungicides.

ABSTRACT: Many studies exist about the selection phase of fungicide resistance evolution, where a resistant strain is present in a pathogen population and is differentially selected for by the application of fungicides. The emergence phase of the evolution of fungicide resistance--where the resistant strain is not present in the population and has to arise through mutation and subsequently invade the population--has not been studied to date. Here, we derive a model which describes the emergence of resistance in pathogen populations of crops. There are several important examples where a single mutation, affecting binding of a fungicide with the target protein, shifts the sensitivity phenotype of the resistant strain to such an extent that it cannot be controlled effectively ('qualitative' or 'single-

SUBMITTER: Hobbelen PH 

PROVIDER: S-EPMC3962370 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature