Quantitative influenza follow-up testing (QIFT)--a novel biomarker for the monitoring of disease activity at the point-of-care.

ABSTRACT:

Background

Influenza infections induce considerable disease burden in young children. Biomarkers for the monitoring of disease activity at the point-of-care (POC) are currently lacking. Recent methodologies for fluorescence-based rapid testing have been developed to provide improved sensitivities with the initial diagnosis. The present study aims to explore the utility of second-generation rapid testing during longitudinal follow-up of influenza patients (Rapid Influenza Follow-up Testing = RIFT). Signal/control fluorescent readouts (Quantitative Influenza Follow-up Testing = QIFT) are evaluated as a potential biomarker for the monitoring of disease activity at the POC.

Methods and findings

RIFT (SOFIA) and QIFT were performed at the POC and compared to blinded RT-PCR at the

SUBMITTER: Chen X 

PROVIDER: S-EPMC3962407 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature