Parity and pancreatic cancer risk: a dose-response meta-analysis of epidemiologic studies.

ABSTRACT:

Background

Previous epidemiologic studies have reported inconsistent results between parity and pancreatic cancer (PC) risk. To our knowledge, a comprehensive and quantitative assessment of this association has not been conducted.

Methods

Relevant published studies of parity and PC were identified using MEDLINE (PubMed) and Web of Science databases until November 2013. Two authors (H-BG and LW) independently assessed eligibility and extracted data. Eleven prospective and 11 case-control studies reported relative risk (RR) estimates and 95% confidence intervals (CIs) of PC associated with parity. Fixed- and random-effects models were used to estimate the summary RR depending on the heterogeneity of effects.

Results

The summary RR for PC comparing the highest versus low

SUBMITTER: Guan HB 

PROVIDER: S-EPMC3962437 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature