Epigenetic differences between shoots and roots in Arabidopsis reveals tissue-specific regulation.

ABSTRACT: DNA methylation and nucleosome densities play a critical role in the regulation of gene expression. While much is known about the mechanisms of transcriptional control that are mediated by these, less is known about the degree to which they are tissue-specific. By comparing DNA methylation, nucleosome densities and transcriptional levels in different tissue types we can gain a clearer understanding of the extent to which these mechanisms influence gene expression in a tissue specific manner. We compared DNA methylation in Arabidopsis shoots and roots and found extensive differences across the genome. We computed DNA methylation differences between roots and shoots at single cytosines and found that one in every 173 cytosines was differentially methylated. In addition we compared DNA methyl

SUBMITTER: Widman N 

PROVIDER: S-EPMC3962533 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature