Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes.

ABSTRACT: Genome-wide association studies have identified a number of autoimmune disease-susceptibility genes. Whether or not these loci share any regulatory or functional elements, however, is an open question. Finding such common regulators is of considerable research interest in order to define systemic therapeutic targets. The growing amount of experimental genomic annotations, particularly those from the ENCODE project, provide a wealth of opportunities to search for such commonalities. We hypothesized that regulatory commonalities might not only delineate a regulatory landscape predisposing to autoimmune diseases, but also define functional elements distinguishing specific diseases. We further investigated if, and how, disease-specific epigenomic elements can identify novel genes yet to be ass

SUBMITTER: Dozmorov MG 

PROVIDER: S-EPMC3962538 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature