Lower stroke risk with lower blood pressure in hemodynamic cerebral ischemia.

ABSTRACT:

Objective

To determine whether strict blood pressure (BP) control is the best medical management for patients with symptomatic carotid artery occlusion and hemodynamic cerebral ischemia.

Methods

In this prospective observational cohort study, we analyzed data from 91 participants in the nonsurgical group of the Carotid Occlusion Surgery Study (COSS) who had recent symptomatic internal carotid artery occlusion and hemodynamic cerebral ischemia manifested by ipsilateral increased oxygen extraction fraction. The target BP goal in COSS was ≤130/85 mm Hg. We compared the occurrence of ipsilateral ischemic stroke during follow-up in the 41 participants with mean BP ≤130/85 mm Hg to the remaining 50 with higher BP.

Results

Of 16 total ipsilateral ischemic strokes that occurr

SUBMITTER: Powers WJ 

PROVIDER: S-EPMC3962994 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature