Alcohol consumption and cognitive impairment in older men: a mendelian randomization study.

ABSTRACT:

Objective

To determine whether alcohol consumption is causally associated with cognitive impairment in older men as predicted by mendelian randomization.

Methods

Retrospective analysis of a cohort study of 3,542 community-dwelling men aged 65 to 83 years followed for 6 years. Cognitive impairment was established by a Mini-Mental State Examination score of 23 or less. Participants provided detailed information about their use of alcohol during the preceding year and were classified as abstainers, occasional drinkers, and regular drinkers: mild (<15 drinks/wk), moderate (15-27 drinks/wk), heavy (28-34 drinks/wk), and abusers (≥35 drinks/wk). We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol

SUBMITTER: Almeida OP 

PROVIDER: S-EPMC3962996 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature