Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study.

ABSTRACT:

Objective

This controlled study investigated associations between comorbidity and medication in patients with polysomnographically confirmed idiopathic REM sleep behavior disorder (iRBD), using a large multicenter clinic-based cohort.

Methods

Data of a self-administered questionnaire on comorbidity and medication use of 318 patients with iRBD and 318 matched controls were analyzed. Comparisons between cases and controls were made using logistic regression analysis.

Results

Patients with iRBD were more likely to report depression (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.3-2.9) and concomitant antidepressant use (OR 2.2, 95% CI 1.4-3.6). Subanalysis of antidepressant agents revealed that the increased use of antidepressants in iRBD was due to selective serot

SUBMITTER: Frauscher B 

PROVIDER: S-EPMC3962997 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature